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Weight Gain and Metabolic Risks Associated with Invega and Abilify
An Overview with Focus on Discontinuation Antipsychotic medications like Invega (paliperidone) and Abilify (aripiprazole) can lead to significant side effects, including weight gain. Here’s an examination, focusing on the discontinuation of Invega, both as a standalone treatment and when combined with Abilify: Weight Gain and Health Risks with Invega: Mechanism: Invega’s weight gain is attributed to its effects on histamine H1 and serotonin 5-HT2C receptors, leading to increased appetite and reduced satiety (De Hert et al., 2012). Prevalence: Clinical data suggests that 10-20% of patients might experience significant weight gain (Correll et al., 2009). Weight Gain with Abilify: Mechanism: Abilify has a relatively lower risk of weight gain but can still contribute in some patients (Citrome, 2013). Combination Therapy: Combining Invega with Abilify might amplify weight…